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Administered as a 1 mg subcutaneous injection 30 to 60 minutes before sleep, Emideltide crosses the blood-brain barrier intact and supports the body's own slow-wave generation while reducing ACTH-driven cortisol at night. It is not a sedative-hypnotic. It does not activate GABA-A receptors. Human trials report longer slow-wave sleep, preserved REM, no documented dependence, and no sedative hangover. 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