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NAD+.
Direct injectable NAD+ bypasses the gut entirely, delivering 100mg/mL straight into tissue to replenish the coenzyme your cells lose every year after 30.
*Clinician-prescribed. Ships from a licensed U.S. pharmacy.
The formulation.
| Compound | NAD+ (Nicotinamide Adenine Dinucleotide) |
| Concentration | 100 mg/ml |
| Format | Sterile injectable solution |
| Route | Subcutaneous |
| Pharmacy | Licensed U.S. Compounding Pharmacy |
NAD+ levels decline roughly 50% between ages 40 and 60. The molecule is a required coenzyme in over 500 enzymatic reactions, including every step of mitochondrial energy production. Oral precursors like NMN and NR must be converted through multiple enzymatic steps before they become NAD+. Each conversion step has its own rate limit. A subcutaneous injection delivers NAD+ directly, bypassing the conversion bottleneck entirely. At 100 mg/ml, this formulation provides a clinically meaningful dose in a single administration.
The mechanism
Why Injectable Beats Oral
Oral NAD+ precursors like NMN and NR require multi-step enzymatic conversion before your body can use them as actual NAD+. Each conversion step loses efficiency. First-pass liver metabolism further degrades the active compound before it ever reaches systemic circulation. Published pharmacokinetic data estimates oral NAD+ bioavailability at less than 5%.
Subcutaneous NAD+ injection bypasses digestion and liver metabolism entirely. The molecule enters tissue directly at full concentration, achieving 100% bioavailability at the injection site. This is not a marginal difference. It is the difference between hoping your body converts a precursor and delivering the finished molecule where it is needed.
Complete your intake
No appointments. No waiting rooms.
Your prescription ships
Compounded by a licensed U.S. pharmacy. Cold-shipped.
Run the course
Follow your provider's dosing schedule.
Safety
What to expect+
Injection site reactions (redness, mild swelling, tenderness) are the most common side effect and typically resolve within 24 hours.
Mild flushing or warmth at the injection site may occur, particularly during the first few doses. This is a normal vasodilatory response.
Transient nausea or lightheadedness has been reported in a small percentage of patients. Injecting slowly and staying hydrated reduces occurrence.
Who should not use this+
Consult your healthcare provider before use if you are pregnant, breastfeeding, or on medication.
Not recommended for individuals with active malignancy without oncologist approval.
Contact your provider if symptoms persist beyond 48 hours.
Regulatory context+
NAD+ is a compounded formulation prepared under section 503A in a licensed U.S. compounding pharmacy. It requires a prescription from a licensed healthcare provider.
Frequently asked
What is NAD+ and why does it matter?+
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell in your body. It is essential for energy production, DNA repair, and the activation of sirtuins, which regulate aging at the cellular level. NAD+ levels decline steadily with age, and this decline is linked to fatigue, cognitive slowing, and accelerated aging. Replenishing NAD+ through injection restores the raw material your cells need to function at a higher level.
Why inject NAD+ instead of taking oral NMN or NR supplements?+
Oral precursors like NMN and NR must be converted through multiple enzymatic steps before your body can use them as NAD+. Each step loses efficiency, and first-pass liver metabolism degrades a significant portion before it reaches circulation. Injectable NAD+ bypasses all of this. It delivers the finished molecule directly into tissue at 100% bioavailability. The result is faster, more consistent elevation of NAD+ levels.
How often do I need to inject?+
Most patients are prescribed 1-2 subcutaneous injections per week. Your provider will determine the exact frequency based on your health profile and goals. Each injection takes less than a minute and can be done at home.
When will I notice results?+
Many patients report improved energy and mental clarity within the first 1-2 weeks. More pronounced benefits, including better recovery, improved skin quality, and sustained focus, typically develop over 4-6 weeks of consistent use. Individual timelines vary based on baseline NAD+ levels and overall health.
Are there side effects?+
The most common side effects are mild injection site reactions: slight redness, tenderness, or swelling that resolves within 24 hours. Some patients experience temporary flushing or warmth at the injection site during the first few doses. Nausea is uncommon but has been reported. Injecting slowly and staying hydrated minimizes side effects. Contact your provider if anything persists beyond 48 hours.
Where is the NAD+ compounded?+
All IVUSE+ NAD+ is compounded at a licensed 503A pharmacy under FDA-regulated conditions. Each batch undergoes sterility and potency testing before release. The medication ships cold-packed directly to your door with clear storage and usage instructions included.
Stack your protocol.
A short course of work. Your cells carry it from there.
$215.00 · Clinician-prescribed · Ships from a licensed U.S. pharmacyThese statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online consultation with a licensed provider who will determine if a prescription is appropriate.