Targeted Peptide Therapy // IVUSE+

NAD+

Direct injectable NAD+ bypasses the gut entirely, delivering 50mg/mL straight into tissue to replenish the coenzyme your cells lose every year after 30.

50MG/ML

Cellular Energy DNA Repair Cognitive Function Anti-Aging Support

Clinician-prescribed. Ships from a licensed U.S. pharmacy.

The Mechanism

Why Injectable Beats Oral

Oral NAD+ precursors like NMN and NR require multi-step enzymatic conversion before your body can use them as actual NAD+. Each conversion step loses efficiency. First-pass liver metabolism further degrades the active compound before it ever reaches systemic circulation. Published pharmacokinetic data estimates oral NAD+ bioavailability at less than 5%. Subcutaneous NAD+ injection bypasses digestion and liver metabolism entirely. The molecule enters tissue directly at full concentration, achieving 100% bioavailability at the injection site. This is not a marginal difference. It is the difference between hoping your body converts a precursor and delivering the finished molecule where it is needed.

Clinical Data

The Evidence

100%

Bioavailability via subcutaneous injection

< 5%

Estimated oral NAD+ bioavailability after first-pass metabolism

91%

Of IVUSE+ NAD+ patients reported noticeable improvements in sustained energy and mental clarity within the first 4 weeks of consistent use.

IVUSE+ patient survey data

Comparison

Oral Precursors vs. Injectable NAD+

Oral Precursors	Injectable NAD+
Requires multi-step enzymatic conversion before becoming usable NAD+	Delivers finished NAD+ molecule directly into tissue. No conversion required
Less than 5% bioavailability after first-pass liver metabolism	100% bioavailability at the injection site. Nothing lost to digestion
Results vary based on individual gut health and absorption capacity	Consistent dosing with predictable serum level increases across patients
Requires daily dosing with inconsistent serum level elevation	1-2 injections per week with sustained elevation between doses
No direct NAD+ delivery. You are relying on your body to build it from parts	Compounded at a licensed 503A pharmacy under strict quality controls

Product Information

Details

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every living cell, required for over 500 enzymatic reactions including sirtuin activation and PARP-mediated DNA repair. It is not a supplement trend. It is a measurable molecule that declines predictably with age. By your 40s, NAD+ levels have dropped by roughly 50% from their peak. This decline correlates directly with reduced mitochondrial output, slower DNA repair, impaired cognitive processing, and accelerated visible aging. Injectable NAD+ restores circulating levels without relying on conversion pathways that limit oral precursors.

Restored mitochondrial energy production: NAD+ fuels the electron transport chain, the mechanism your cells use to generate ATP. More NAD+ means more available cellular energy. Sharper cognitive function: NAD+ supports sirtuin-mediated neuroprotection, contributing to improved focus, mental clarity, and processing speed. Accelerated DNA repair: PARP enzymes consume NAD+ to fix DNA strand breaks. Adequate NAD+ levels keep this repair system running at full capacity. Optimized metabolic function: NAD+ regulates key metabolic pathways including fatty acid oxidation and glucose metabolism, supporting body composition and sustained energy output.

Administer subcutaneously (abdomen or upper thigh) per your provider's prescribed protocol. Store refrigerated at 36-46°F (2-8°C). Do not freeze. Protect from light. Rotate injection sites to minimize tissue irritation. Use alcohol swabs to clean the injection site before each administration.

Injection site reactions (redness, mild swelling, tenderness) are the most common side effect and typically resolve within 24 hours. Mild flushing or warmth at the injection site may occur, particularly during the first few doses. This is a normal vasodilatory response. Transient nausea or lightheadedness has been reported in a small percentage of patients. Injecting slowly and staying hydrated before administration reduces occurrence. Contact your provider if symptoms persist beyond 48 hours.