IVUSE / Nicotinamide Riboside Dosing Protocol
YOUR PROTOCOL V1.0 // SubQ

Nicotinamide
Riboside Dosing

A direct NAD+ precursor that supports cellular energy, mitochondrial function, and metabolic resilience. Inject subcutaneously in the AM or PM. Flexible timing, consistent cadence.

First time injecting? View our step-by-step Injection Tutorial before your first dose.

Concentration
100 mg/mL
315 units per vial
Method
Subcutaneous
Abdomen or thigh
Frequency
3x per week
AM or PM, consistent cadence
Dose
25 units
Do not exceed 50 units
Cycle
12 weeks on
2 weeks off
Supply
3 vials
Per 12-week cycle
[01]

Dosing Schedule

Administer 25 units three times per week. Inject in the AM or PM, whichever fits your routine. Space your doses evenly across the week to maintain steady NAD+ precursor support.

Day Dose Notes
Monday 25units NR
Tuesday Rest day
Wednesday 25units NR
Thursday Rest day
Friday 25units NR
Saturday Rest day
Sunday Rest day
Tip: The schedule above uses Mon/Wed/Fri as example days. You can adjust to fit your routine. The key rule: keep one rest day between doses and inject at roughly the same time each dosing day.
Do not exceed 50 units per injection. Higher doses do not improve results and increase the likelihood of warmth, flushing, or injection site discomfort. Stay at 25 units unless directed otherwise by your provider.
[02]

Timing & Tolerance

Nicotinamide Riboside can be injected in the AM or PM. Many find AM injections energizing and PM injections better tolerated. NR is generally milder than NAD+, but a slow push still helps minimize warmth at the injection site. Rotate sites with each dose.

Sample Weekly Timeline
MON
TUE
WED
THU
FRI
SAT
SUN
NR (25 units)
Rest
Inject slowly. A slow push over 30 to 60 seconds reduces any warmth or sting at the site. Rotating between abdomen and thigh prevents irritation and keeps absorption consistent.
[03]

Cycling Protocol

Nicotinamide Riboside is administered in cycles. Run the protocol for 12 consecutive weeks, then take 2 weeks off before starting the next cycle. You will need 3 vials to complete one full 12-week cycle.

14-Week Cycle Overview
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14
Active (12 weeks)
Off (2 weeks)
The 2-week off period lets your cellular pathways reset so the next cycle stays effective. Continue any other protocols you are running as prescribed. The off cycle applies to Nicotinamide Riboside only.
Next Cycle

Ready to Reorder?

Order your next vials before your off-cycle ends so you are ready to start again on schedule. You will need 3 vials per cycle.

Reorder Nicotinamide Riboside
[04]

Injection Quick Reference

Follow these steps for each injection. If this is your first time, review the Injection Tutorial for a full walkthrough.

  • 01
    Wash hands thoroughly with soap and water.
  • 02
    Draw 25 units into your syringe. Never exceed 50 units.
  • 03
    Clean the injection site with an alcohol swab. Rotate between abdomen and thigh.
  • 04
    Pinch the skin and insert the needle at a 45-degree angle.
  • 05
    Inject slowly over 30-60 seconds to minimize warmth or sting at the site.
  • 06
    Dispose of the syringe in a sharps container. Never recap or reuse needles.
[05]

Storage

Store your Nicotinamide Riboside vial refrigerated at 36-46°F (2-8°C) after reconstitution. Keep away from direct sunlight. NR is light-sensitive, so a closed, dark area of the fridge is ideal. Unreconstituted vials can be stored at room temperature.
[06]

Support

Questions about your protocol, dosing, or anything else? Reach our team directly at support@ivuseplus.com. We typically respond within 24 hours.

Don't run out
Order your next Nicotinamide Riboside cycle
Reorder

This protocol is for informational purposes. Consult your healthcare provider before beginning any peptide protocol. If you experience persistent redness, swelling, or discomfort at the injection site, discontinue use and contact support.

IVUSE Protocol // NR // SubQ