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KPV.
Compounded KPV is a tripeptide derived from alpha-MSH. It interrupts the NF-kB inflammatory pathway inside the cell, with documented effects on gut and skin inflammation in preclinical research.
*Clinician-prescribed. Ships from a licensed U.S. pharmacy.
The formulation.
| Peptide | KPV (Lys-Pro-Val) |
| Derived From | Alpha-MSH C-terminal tripeptide |
| Concentration | 10 mg/ml |
| Format | Sterile injectable solution |
| Route | Subcutaneous |
| Pharmacy | Licensed U.S. Compounding Pharmacy |
Most anti-inflammatory supplements work downstream, after the damage is already done. KPV works upstream, inside the cell, blocking NF-kB before it can turn on the genes that produce TNF-alpha, IL-1, and IL-6. The difference is specificity: one inflammatory pathway goes quiet while the rest of the immune system stays intact. That is the difference between suppression and precision.
The mechanism
Inflammation has one main switch. KPV is small enough to reach it.
Most chronic inflammation runs through one transcription factor, NF-kB. KPV is transported into cells by PepT1, then blocks NF-kB nuclear translocation. Without NF-kB in the nucleus, transcription of TNF-alpha, IL-1, IL-6, and COX-2 drops. The result is a targeted reduction in cytokine output at the cellular level, documented in gut, skin, and immune cell lines.
KPV comes from alpha-MSH, the hormone that tells skin to make pigment, but it leaves that job behind. In animals whose pigment receptor did not work at all, KPV still reduced inflammation. The anti-inflammatory effect runs on a separate track from anything that changes your skin tone.
Complete your intake
No appointments. No waiting rooms.
Your prescription ships
Compounded by a licensed U.S. pharmacy. Cold-shipped.
Run the course
Follow your provider's dosing schedule.
Safety
What to expect+
KPV is generally well-tolerated. The most commonly reported effects are injection-site redness, transient itching, mild fatigue, and headache.
These effects are typically mild and resolve within 24 to 48 hours.
Antibody formation is theoretically possible with any peptide but is not commonly reported with KPV.
Who should not use this+
Do not use if you have an active malignancy under treatment.
Do not use if you are pregnant or breastfeeding.
Do not use if you have a known hypersensitivity to alpha-MSH-derived peptides.
Discuss any autoimmune diagnosis with your provider before starting.
Stop use and contact your provider if you experience persistent rash, swelling, or signs of allergic reaction.
Regulatory context+
KPV is a compounded formulation prepared under section 503A in a licensed U.S. compounding pharmacy. It requires a prescription from a licensed healthcare provider.
Frequently asked
What is KPV?+
KPV is a three-amino-acid fragment (Lys-Pro-Val) derived from alpha-MSH, a naturally occurring peptide in the body. It was identified for its ability to modulate inflammatory signaling without the pigmentation effects of the full alpha-MSH molecule.
How does KPV work?+
KPV enters cells and interacts with inflammatory signaling pathways, particularly NF-kB, which controls the expression of genes involved in immune response. By modulating this pathway, KPV helps reduce the overproduction of pro-inflammatory cytokines while preserving normal immune function.
What can I expect from KPV?+
Many people use KPV for inflammatory support, particularly related to gut health and skin conditions. Because it targets upstream inflammatory signaling rather than masking symptoms, improvements tend to build gradually over several weeks of consistent use. Results vary by individual.
Are there any side effects?+
KPV is generally well tolerated. The most common side effects are mild injection site reactions such as redness or soreness, which typically resolve within 24 hours. Because KPV is a fragment of a naturally occurring human peptide, systemic side effects are uncommon.
How is KPV made and shipped?+
It starts with a short online medical intake, and if it's a fit, a licensed U.S. provider writes the prescription. From there it's compounded at a licensed 503A pharmacy and batch tested by a third party for sterility and potency. Then it's shipped cold-packed right to your door.
What's the best way to buy KPV?+
You've got two options. You can buy a one-time single vial, or you can go with the Build Your Stack subscription, which lets you mix and match the compounds in your monthly stack, starting at $189 per month. For ongoing use the stack is the better value, and you can pause, skip, or cancel anytime.
A short course of work. Your cells carry it from there.
$213.00 · Clinician-prescribed · Ships from a licensed U.S. pharmacyThese statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online consultation with a licensed provider who will determine if a prescription is appropriate.