Licensed US pharmacy Built for women 40+ Free, discreet shipping
NR + NAD+ NR plus NAD protocol
Why It Works
✓NAD+ is the molecule cells run on, and levels fall as you age
✓A single dose of NR raised whole-blood NAD+ by 2.7x (Trammell et al., Nature Communications, 2016)
✓Daily NR held NAD+ elevated across six weeks (Martens et al., Nat. Comms, 2018)
✓The subcutaneous route skips the gut and liver first pass that limits oral NAD+
✓NR has the largest published human dataset of the NAD+ precursors
✓Unlike NMN, NR isn't consumed by the CD38 pathway
Targeted NAD+ Therapy

NR + NAD+

The NAD+ Protocol, Built as a System
4.2 · 1,242 reviews

Built to support:

  • ✓ Steadier daytime energy
  • ✓ Focus and mental clarity
  • ✓ Recovery from training and travel
  • ✓ Better tolerated, with less of the NAD+ flush
  • ✓ Cellular energy production
  • ✓ Two molecules, one protocol
Choose your plan:
Most Popular · Quarterly
$449 $399 /mo · $13.30/day
Billed $1,197 every 90 days · ships once
  • ✓ Both molecules: NAD+ and NR, dosed together
  • ✓ Pause or step down anytime, no step-ups
  • ✓ Not charged if you are not a candidate
Start Your Protocol
Board-certified providers · Licensed US pharmacy
Licensed 503A/503B pharmacy
Physician-prescribed
HIPAA compliant
Cold-chain shipped
Dr. Linnelle Grier
Medical Director

"A single shot raises NAD+ for a moment. Pairing it with NR is what keeps cells producing it between doses. That is why we prescribe the two together."

Not for use in pregnancy, breastfeeding, active cancer treatment, or with PARP inhibitors. A provider reviews your history before prescribing.
NR + NAD+ Protocol

The NAD+ everyone wants.
Without the part everyone dreads.

The flush, the nausea, the hours-long burn. That is the part everyone dreads, and the part NR is in the protocol to soften. NAD+ makes the deposit. NR keeps the supply line stocked. You get the steadier afternoons, without the dose people quit over.

What It Supports

Made, not borrowed

Energy that holds

NAD+ is the coenzyme behind cellular energy. The protocol keeps the level stocked so the afternoon stays steady. The hum people describe, not a stimulant spike and the crash behind it.

Focus through the afternoon

Support for the fog that shows up in the 40s, worked at the cellular level instead of stacked on another nootropic. Most people describe it building over the first weeks, not switching on overnight.

Recovery you stopped noticing

Support for the bounce-back after training, travel, and the late nights that used to cost more than they do now. The recovery the body gets slower at, and the part NR is built to carry without the burn.

NAD+ science has been covered in
In Their Words

See why women call it the honest one

★★★★★

"Almost quit around week three when nothing much was happening. Glad I didn't. Now I can get through afternoons without hitting a wall so much."

Maya R., 47
★★★★★

"I liked how honest they were up front. Took time to work but once it did it stayed pretty steady for me."

Joanne P., 53
★★★★★

"I avoided IVs cause of nausea stories. Didn't want that. This shot is quick and easy, no issues so far."

Faith H., 49
Why Women Choose It

Built for her, not a dashboard

The category is fronted by men and biomarker dashboards. This was built for the woman those dashboards skip.

4.2 average rating · 1,242 verified reviews
What's In The Protocol

Two molecules, deliberately paired

NAD+ makes the direct deposit. Nicotinamide Riboside (NR), a form of vitamin B3, is the supply line: the precursor your cells convert into NAD+, and the part that protects what is already there.

NAD+ and NR injection vials, paired
503A/503B compounded
Physician-dosed
At-home subcutaneous
Cycled 12 on, 2 off
The Whole Idea
NAD+ runs the cell. Your body makes less with age.
The Pairing Logic

Why both. Not either.

NAD+ alone
NR alone
The protocol
Uptake into cells
Poor intact uptake
Crosses efficiently
Direct deposit plus efficient uptake
Tolerability
Flush, nausea when pushed
Far better tolerated
NR softens the experience
Keeps cells producing
No
Yes
Yes
Protects existing NAD+
No
Yes, slows CD38
Yes
The part nobody wants to talk about

You have heard how NAD+ feels.

"A nauseating, hours-long marathon."

"Kind of burns going in."

"Flushing, warmth, a heavy flush."

That reaction is the most common complaint in the category, and it is exactly why NR is in the protocol. NR is the better-tolerated way to raise the same coenzyme, the precursor your cells convert into NAD+. It carries what NAD+ alone cannot, so you get the deposit without dreading the dose.

Set Your Expectations

What the first eight weeks feel like

We tell you the curve before you start, including the quiet stretch most brands hope you do not notice. Knowing it is coming is what gets you through it.

Days 1 to 10
The first shift

Energy and focus often move first. Many people notice a steadier afternoon in the first week to ten days.

Weeks 2 to 3
The quiet stretch

This is the part most people quit on. The early lift settles and the deeper work has not surfaced yet. It is normal. It is the protocol working underneath, not failing.

Weeks 4 to 6
The build

The deeper cellular benefits land. Recovery, clarity, and the steady hum people describe tend to settle in here.

Weeks 6 to 8 and on
The pleasant surprise

Skin, hair, and sleep are often reported here, usually as a surprise rather than the reason people started. Not guaranteed, and it varies.

The Science

What the studies showed

Framed as what published research observed, not a guaranteed personal outcome. Most of this evidence comes from oral NR studies; the protocol delivers the same molecule by subcutaneous injection.

✓

A single oral dose of NR raised whole-blood NAD+ 2.7x in healthy adults.Trammell et al., Nature Communications, 2016

✓

Daily oral NR sustained a 60% increase in NAD+ over six weeks in middle-aged and older adults.Martens et al., Nature Communications, 2018

✓

NR has been shown to inhibit CD38, the enzyme that accelerates NAD+ decline, protecting the reserve as well as feeding production.Kao et al., JACS Au, 2024

✓

NAD+ falls measurably with age, with a first meaningful drop around the 40s, the window this protocol is built for.

Complete vs Partial

Compared to single-molecule products

NR and NAD+ vials
This protocol
Generic single-molecule supplement
Other products
Both molecules
✓ NAD+ and NR
× One or the other
Tolerability built in
✓ NR softens it
× Flush often noted
Flat, honest pricing
✓ No step-ups
× Month-two step-ups common
Honest about the ceiling
✓ Says what it cannot do
× Tends to overclaim
Compounded, prescribed
✓ 503A/503B, physician
~ Varies widely
One Regimen

The whole shelf.

The shelf runs to 34 options, grouped by what people are trying to feel, not by mechanism, because nobody buys CD38 inhibition. Nobody buys the whole shelf either. Three or four from each group is the real basket, and even that runs six to nine hundred a month. The protocol replaces the juggling act, one source instead of a cabinet.

What the shelf costs34 options · per month
Three to four per group · premium-tier, est.$600 to $900 / mo
One regimen$399 / month

Stop assembling the protocol. Start the protocol.

Per-item and total figures are retail estimates for premium-tier versions of the products people commonly stack to reach for this outcome territory, based on three to four picks per group rather than the full list, and vary by brand and dose. This is a consolidation and convenience comparison, not a claim that the protocol is more effective than any supplement listed.

Questions

Frequently asked questions

Each covers the other's weakness. NAD+ is the direct deposit, but it's poorly absorbed intact and harder to tolerate. NR crosses into cells efficiently, is better tolerated, keeps your cells producing their own NAD+, and protects what's already there. Together they're a protocol: the deposit plus the supply line.
Less likely than with NAD+ alone, though not zero. The flush, warmth, and nausea are the most common complaint about NAD+, especially when pushed fast by IV, and the better-tolerated NR route is the reason it's in this protocol. Injection-site redness or mild swelling can still happen and usually settles quickly.
Oral capsules go through the gut, where uptake varies, then through the liver first. The subcutaneous route skips that first pass. NMN is one step closer to NAD+ but is a larger molecule with debated uptake, and CD38 can consume it. NR has the larger published human dataset, and unlike NMN it isn't consumed by the CD38 step.
Many people notice energy and focus shifts within seven to ten days. Then there's often a quiet stretch around weeks two to three where it feels like not much is happening. That's normal and expected. The deeper benefits tend to build over four to six weeks. Results vary and aren't guaranteed.
A fair question, and we put it on the page on purpose. This is feel-based cellular support, not a proven lifespan extender or a cure. The NR science behind it is published, and the one-time path exists so you can feel it for yourself before committing to anything ongoing.
The monthly and quarterly paths are ongoing; the one-time path is a single month with no commitment. Pricing's flat, with no month-two step-up. The monthly plan has a three-month minimum before you can cancel. Quarterly and one-time have no minimum, and you can pause or step down anytime.
A subcutaneous injection at home, on a symmetric weekly cadence across both molecules. Everything ships with it: vials, syringes, alcohol prep pads, and a dosing chart. The shot's a slight pinch that lasts about a second.
Don't use if pregnant, breastfeeding, undergoing active cancer treatment, or taking PARP inhibitors. Disclose all conditions and medications during your intake. A provider reviews each case before prescribing, and you aren't charged if you aren't a candidate.
Both molecules are compounded by a licensed 503A/503B pharmacy under physician prescription, prepared per patient. Cold-chain packaging in a discreet box. Quarterly ships once per 90 days. Store refrigerated and rotate injection sites.
Because these are personalized compounded medications, prepared per patient, they generally can't be returned once dispensed. Two things protect you instead. You aren't charged if a provider determines you aren't a candidate, and you can pause or step down anytime, so you aren't locked into the next cycle.
The Honest Ceiling

What this does. What it doesn't.

We would rather name the ceiling ourselves than sell you past it.

What it does
  • Supports steadier daytime energy
  • Supports focus and mental clarity
  • Supports recovery from training, travel, and the odd bad week
  • May support deeper, easier sleep for some, usually later on
  • Delivers a precursor your cells convert into NAD+, efficiently
  • Is better tolerated than NAD+ on its own
What it doesn't
  • It is not a proven lifespan extender
  • It is not a cure or treatment for any condition
  • It does not work overnight. Results build over weeks
  • It supports the body's machinery. It does not reverse aging
  • It is not a replacement for sleep, movement, or medical care

Compounded medication dispensed under physician prescription via a licensed 503A/503B pharmacy. Not FDA-approved. Not intended to diagnose, treat, cure, or prevent any disease. Feel-based support, not a proven lifespan extender. Individual response varies. Disclose all medications and medical conditions during your async telehealth intake.

Who It's For

Built for the 40+ year cliff

The category is fronted by men with biomarker dashboards. This protocol was built for her.

Built for
  • Women in their 40s and 50s who do not feel like themselves and want a clear way in
  • People who tried oral NAD+ or NMN and felt nothing
  • People who want steadier afternoons without the IV-chair burn
  • People who prefer flat, honest pricing over discount games and step-ups
  • GLP-1 patients already injecting weekly, looking at maintenance
Not built for
  • People who want overnight results. This builds over weeks
  • People looking for a proven cure or a lifespan guarantee
  • People who want the cheapest possible option regardless of route
  • Anyone pregnant, breastfeeding, or in active cancer treatment
  • People not comfortable with a subcutaneous shot
Why It Matters

Why a licensed pharmacy matters

The NAD+ space is full of gray-market vials sold without oversight. Here is what makes us different.

01
Prescribed, not sold

A board-certified provider reviews each intake. Nothing ships without that review.

02
Compounded to order

A licensed 503A/503B pharmacy compounds each order.

03
Tracked end to end

Cold-chain shipping.

Refill the coenzyme
every cell runs on

NAD+ makes the direct deposit. NR keeps the supply line stocked and protects what you have. One protocol, flat pricing, the steadier afternoons without the part you dread.

Start Your Protocol