PT-141 Nasal Spray.
A melanocortin agonist that acts on MC4R receptors in the hypothalamus. Targets desire and arousal pathways in the central nervous system. On-demand dosing, 15 to 30 minute onset.
*Clinician-prescribed. Ships from a licensed U.S. pharmacy.
The formulation.
| Compound | Bremelanotide (PT-141) |
| Concentration | 5 mg/mL |
| Format | 10 mL Nasal Spray Bottle |
| Route | Intranasal |
| Onset | 15–30 minutes |
| Duration | 4–8 hours |
| Storage | Refrigerate 36–46°F |
| Pharmacy | Licensed U.S. compounding pharmacy |
The mechanism
PT-141 Acts on the Brain, Not the Vascular System
Bremelanotide is a synthetic neuropeptide that stimulates melanocortin 4 receptors (MC4R) in the hypothalamus. This triggers dopaminergic pathways that control sexual desire and arousal. Unlike PDE5 inhibitors that work on blood flow, PT-141 acts centrally on the nervous system. Intranasal delivery provides rapid absorption with onset in 15 to 30 minutes.
Complete your intake
No appointments. No waiting rooms.
Your prescription ships
Compounded by a licensed U.S. pharmacy. Cold-shipped.
Run the course
Follow your provider's dosing schedule.
Safety
What to expect+
Common mild side effects may include nasal congestion, nausea, flushing, headache, fatigue, and temporary blood pressure increase.
Avoid use with uncontrolled hypertension, cardiovascular disease, or known hypersensitivity to melanocortin peptides. Not for use during pregnancy or breastfeeding. Avoid concurrent use with CNS stimulants.
Consult your prescribing provider before starting any new protocol.
Who should not use this+
Avoid use with uncontrolled hypertension or cardiovascular disease.
Do not use if you have known hypersensitivity to melanocortin peptides.
Not for use during pregnancy or breastfeeding.
Avoid concurrent use with CNS stimulants.
Maximum 1 dose per 24 hours.
Regulatory context+
Bremelanotide was FDA-approved as Vyleesi in June 2019 for hypoactive sexual desire disorder in premenopausal women. This is a compounded intranasal formulation prepared under section 503A/503B in a licensed U.S. compounding pharmacy. It requires a prescription from a licensed healthcare provider.
Frequently asked
What is Bremelanotide (PT-141)?+
Bremelanotide is a synthetic neuropeptide that stimulates melanocortin receptors in the brain to support sexual desire and arousal. It acts on the central nervous system rather than the vascular system.
How does PT-141 differ from PDE5 inhibitors?+
PDE5 inhibitors work on blood flow and vascular mechanics. PT-141 acts centrally in the hypothalamus on melanocortin receptors, targeting the desire and arousal pathways directly. This makes it a different approach, particularly for psychological or hormonal causes of sexual dysfunction.
Does it work for both men and women?+
Yes. Bremelanotide has been studied for use in both men and women experiencing hypoactive sexual desire disorder (HSDD), arousal disorders, and psychogenic erectile dysfunction.
How quickly does it work?+
Typical onset is 15 to 30 minutes after intranasal administration, with effects lasting 4 to 8 hours.
How often can I use it?+
Maximum 1 dose per 24 hours. Your prescribing provider will determine the appropriate dosing frequency for your protocol.
What are the side effects?+
Common mild effects include nasal congestion, nausea, flushing, headache, fatigue, and temporary blood pressure increase. Consult your provider if any side effects persist.
Who should not use this product?+
Avoid use if you have uncontrolled hypertension, cardiovascular disease, or known hypersensitivity to melanocortin peptides. Not for use during pregnancy or breastfeeding, or with CNS stimulants.
How should I store it?+
Store in a refrigerator at 36 to 46 degrees F (2 to 8 degrees C). Do not freeze. Use within 30 days of opening.
Do I need a prescription?+
Yes. Bremelanotide Nasal Spray is a compounded medication that requires a prescription from a licensed healthcare provider.
Is this the same compound as the FDA-approved injection?+
Bremelanotide is the same active compound approved as Vyleesi in 2019. This is a compounded intranasal formulation with a different concentration and delivery method than the FDA-approved subcutaneous injection.
Stack your protocol.
Sexual desire starts in the brain. This is the peptide that reaches it.
$269.00 · Clinician-prescribed · Ships from a licensed U.S. pharmacyThese statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online consultation with a licensed provider who will determine if a prescription is appropriate.
