Nicotinamide Riboside
NR at 100mg/mL. A direct precursor to NAD+, the coenzyme behind cellular energy, DNA repair, and every sirtuin signal that slows aging. Injected subcutaneously to bypass the gut and the absorption loss that limits oral supplements. Three doses per week. Twelve weeks on, two off.
Clinician-prescribed. Ships from a licensed U.S. pharmacy.
NAD+ falls with age. Energy, clarity, and repair fall with it.
NAD+ is the cofactor behind sirtuin signaling, PARP-mediated DNA repair, and the electron transport chain in every mitochondrion. Tissue NAD+ declines measurably with age, with studies documenting reductions of 50 percent or more across the adult lifespan. Nicotinamide Riboside is a ribosylated form of vitamin B3 that enters cells through nucleoside transporters and converts to NAD+ in two enzymatic steps. Subcutaneous delivery bypasses the gut and the absorption variability that limits oral NAD+ precursors.
What changes when your cells stop running on empty.
NR raises the NAD+ pool that sirtuins and PARPs draw from. The changes people notice first: steadier energy through the afternoon, fewer days lost to brain fog, and faster recovery after training. By weeks four to eight. Skin quality, sleep depth, and visible markers lag behind and depend on where you start. This is not a miracle molecule. It is the raw material your cells already know how to use, delivered in a form your gut cannot diminish.
Oral NR or NMN vs. Injectable NR
| Oral NR or NMN | Injectable NR |
|---|---|
| Daily 250 to 1,000 mg pills | ~25 mg subcutaneous, 3 days per week |
| Routed through the stomach and liver | Bypasses the gut and first-pass metabolism |
| Absorption varies person to person | Delivered consistently by injection |
| Sold over the counter | Prescribed by a licensed provider, compounded by a 503A/503B pharmacy |
| Months of consistent dosing required to see NAD+ rise plateau | 12-week structured cycle with a 2-week off window |
NR vs. Other NAD+ Precursors
| NR | Other NAD+ Precursors |
|---|---|
| Nicotinamide Riboside (NR) | NMN, Niacin (NA), Nicotinamide (Nam) |
| Two enzymatic steps to NAD+ via the NRK pathway | NMN: one enzymatic step to NAD+ but larger molecule with debated cellular uptake mechanism |
| Enters cells through dedicated nucleoside transporters | Niacin: causes flushing at therapeutic doses, limiting compliance |
| Largest human RCT base: 140-subject study showed 22 to 142% NAD+ rise, dose-dependently | Nicotinamide: can inhibit sirtuin activity at high concentrations |
| GRAS-designated ingredient (Niagen) | Smaller human RCT datasets than NR |
Details
Here is the problem: your body makes less NAD+ every year. By middle age, tissue levels have dropped significantly, and the systems that depend on it, energy, repair, cognitive sharpness, start to feel the shortfall. That gradual decline is what people describe when they say they are running on empty despite doing everything right.
Most NAD+ supplements are pills. They work, but they have to survive your stomach, pass through your liver, and compete with the variability of individual gut absorption. This protocol takes a different route. Compounded injectable NR at 100 mg/mL, delivered subcutaneously three times per week. Lower doses, higher consistency, no digestive loss.
One thing worth understanding: NR does not produce overnight results. It rebuilds a cellular foundation. The timeline is weeks, not days. And it depends on where you start.
Prescribed via async telehealth. Filled by a licensed 503A/503B compounding pharmacy. Cycled 12 weeks on, 2 weeks off.
The changes people on NAD+ precursor protocols report most consistently:
Steadier daytime energy without stimulant crashes
Reduced afternoon brain fog and sharper word recall
Faster recovery between workouts
Improved sleep quality and morning alertness
These changes typically emerge between weeks 4 and 8 and depend on baseline NAD+ status, sleep quality, and overall health. NR does not produce overnight results. It rebuilds a foundation.
Cycle: 12 weeks on, 2 weeks off.
Vial volume: 315 units per vial, approximately 12 injections per vial.
Vials per cycle: 3 vials for one complete 12-week cycle.
Administer subcutaneously into the abdomen or upper thigh. Rotate injection sites. Store refrigerated at 36 to 46 degrees Fahrenheit. Protect from light. Discard 28 days after first puncture.
Mild injection site reactions such as redness or tenderness
Flushing or warmth
Headache
Gastrointestinal discomfort, less common with injectable vs. oral
NAD+ injectable products are compounded medications and are not FDA-approved. The FDA has documented adverse events with some compounded NAD+ injectables, including chills and nausea, typically associated with higher-dose IV protocols rather than low-dose subcutaneous administration.
Do not use if you are pregnant, breastfeeding, or have active malignancy. Disclose all medications and medical conditions during your clinical intake.
Disclaimer and Transparency
Important Information About Compounded Injectables
- Compounded medications are not reviewed or approved by the FDA and do not undergo the same pre-market evaluation as FDA-approved drugs.
- IVUSE peptide injections are prepared using peptide ingredients by FDA-registered, U.S.-licensed 503A & 503B compounding pharmacies, where available and clinically appropriate.
- Availability and formulation may vary based on state regulations, evolving clinical guidance, and pharmacy partners.
All prescriptions, treatment decisions, and care plans are made independently by licensed healthcare providers using their professional judgment. Images and product depictions are for illustration only; actual packaging and supplies may vary.
*If you are interested in a prescription product, IVUSE will coordinate a telehealth visit with a licensed medical provider who will determine whether you are an appropriate candidate based on your health profile and current standards of care. If approved, a prescription will be issued and filled by one of our partner pharmacies. All prescriptions are subject to provider discretion and clinical appropriateness.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. All information provided here is for educational purposes only and does not replace personalized medical advice from a qualified healthcare professional.
Stop the medication and contact your provider if you experience persistent or concerning symptoms. Seek immediate medical care if you develop signs of a severe allergic reaction (such as hives, facial swelling, or difficulty breathing) or any rapidly worsening symptom.
What happens next
Choose Your Protocol
No consultation fee. No hidden costs. Single vials or a full 12-week cycle.
Complete Your Clinical Intake
A board-certified clinician reviews your health history, medications, and goals. Asynchronous. No appointments. No waiting rooms.
Your Prescription Ships
Compounded by a licensed U.S. pharmacy. Delivered to your door in 2-4 business days. Cold-shipped when required.
Stack Your Protocol
NAD+
NAD+ fuels the repair and energy systems inside every cell. NR is a direct precursor that replenishes it. One delivers the finished molecule. The other gives your body the building block to make more on its own. Run both during the same cycle for full-spectrum NAD+ support.
Tired isn't a personality trait. It's a signal your cells are running low.
Nicotinamide Riboside is a direct precursor to NAD+, the coenzyme behind cellular energy, DNA repair, and sirtuin signaling. Injectable. Clinician-prescribed. Delivered to your door in 2 to 4 business days.
Compounded medication dispensed under physician prescription via a licensed 503A/503B compounding pharmacy. Not FDA-approved. Not intended to diagnose, treat, cure, or prevent any disease. Individual response varies. Disclose all medications and medical conditions during your async telehealth intake.
