Tesamorelin
Tesamorelin at 5mg/mL. The only FDA-approved growth hormone therapy proven to target the deep fat around your organs, the kind you can't crunch away. 44 amino acids, engineered for precision. Stabilized. Targeted. Take as a standalone, or combine with GLP-1's.
Clinician-prescribed. Ships from a licensed U.S. pharmacy.
Visceral Fat. Measured, Imaged, Reduced.
Visceral adipose tissue wraps your organs. It is metabolically distinct from the subcutaneous fat you can pinch. It secretes inflammatory cytokines, drives insulin resistance, and correlates with cardiovascular risk independently of total body weight. Standard dieting reduces subcutaneous fat more readily than visceral. Tesamorelin stimulates pulsatile GH release that selectively mobilizes visceral fat stores. In Phase III trials, CT scans showed an average 15-18% reduction in visceral adipose tissue at 26 weeks. Body weight did not change. Waist circumference did.
The Evidence
Tesamorelin (brand name Egrifta) received FDA approval in November 2010 for reduction of excess abdominal fat in HIV-associated lipodystrophy.
This Changes Your Body Without Changing Your Weight
Tesamorelin targets visceral fat through pulsatile growth hormone release. The result is measurable reduction in the fat that surrounds your organs, improved metabolic markers, and a leaner waistline, without the scale moving significantly.
Sermorelin (GHRH 1-29) vs. Tesamorelin (Modified GHRH 1-44)
| Sermorelin (GHRH 1-29) | Tesamorelin (Modified GHRH 1-44) |
|---|---|
| 29-amino acid truncated GHRH analog | 44-amino acid full-length GHRH analog with N-terminal stabilization |
| Short half-life (10-20 minutes), requires daily bedtime dosing | Enhanced stability from trans-3-hexonoic acid modification |
| General GH restoration for sleep, recovery, body composition | FDA-approved specifically for visceral fat reduction |
| No Phase III clinical trial data for visceral fat reduction | Two Phase III trials with CT-verified results in 800+ patients |
| Broad GH axis support without compartment-specific targeting | Selective visceral adipose tissue targeting documented on imaging |
| Available through compounding pharmacies | Available through compounding pharmacies for off-label use |
GLP-1 RECEPTOR AGONISTS VS. TESAMORELIN
| GLP-1 RECEPTOR AGONISTS VS. TESAMORELIN | GLP-1 RECEPTOR AGONISTS VS. TESAMORELIN |
|---|---|
| Targets total body weight through appetite suppression | Targets visceral fat through pulsatile growth hormone release |
| Reduces subcutaneous and visceral fat indiscriminately | Selective reduction of organ-surrounding adipose tissue on CT imaging |
| Scale-dependent results. Weight loss is the metric. | Composition-dependent results. Waist circumference is the metric. |
| Muscle mass loss reported in 20-40% of patients | Weight-neutral by design. Preserves lean mass. |
| Requires ongoing use to maintain appetite suppression | Works through the body's endogenous growth hormone axis |
| Systemic mechanism affecting hunger, satiety, gastric emptying | Compartment-specific mechanism targeting visceral fat stores |
Details
FDA-approved in 2010 under the brand name Egrifta, tesamorelin is the first and only medication specifically approved to reduce excess visceral fat, the deep, hidden fat packed around your organs.
Here's how it works: tesamorelin signals your pituitary gland (a small structure at the base of your brain) to release growth hormone the way it naturally would, in controlled pulses, not a constant flood. Your body's own feedback system stays intact. You're not overriding anything. You're restoring a signal.
What separates tesamorelin from other peptides is the clinical proof. Two large-scale Phase III trials enrolled over 800 patients and showed statistically significant reductions in visceral fat, confirmed by CT imaging, not just a scale.
One thing worth understanding: tesamorelin is weight-neutral by design. It does not reduce body weight, because the problem it solves is not weight. It's where the fat lives. You may weigh the same and be meaningfully healthier.
Emerging research shows cognitive benefits. A 2015 study demonstrated improved verbal memory and executive function in adults over 60. Separately, tesamorelin reduces hepatic fat accumulation, improving liver function markers in patients with non-alcoholic fatty liver profiles.
Your prescribing provider will determine cycle length based on clinical goals and imaging data. Store refrigerated at 36 to 46 degrees Fahrenheit. Protect from light.
Disclaimer and Transparency
Important Information About Compounded Injectables
- Compounded medications are not reviewed or approved by the FDA and do not undergo the same pre-market evaluation as FDA-approved drugs.
- IVUSE peptide injections are prepared using peptide ingredients by FDA-registered, U.S.-licensed 503A & 503B compounding pharmacies, where available and clinically appropriate.
- Availability and formulation may vary based on state regulations, evolving clinical guidance, and pharmacy partners.
All prescriptions, treatment decisions, and care plans are made independently by licensed healthcare providers using their professional judgment. Images and product depictions are for illustration only; actual packaging and supplies may vary.
*If you are interested in a prescription product, IVUSE will coordinate a telehealth visit with a licensed medical provider who will determine whether you are an appropriate candidate based on your health profile and current standards of care. If approved, a prescription will be issued and filled by one of our partner pharmacies. All prescriptions are subject to provider discretion and clinical appropriateness.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. All information provided here is for educational purposes only and does not replace personalized medical advice from a qualified healthcare professional.
Stop the medication and contact your provider if you experience persistent or concerning symptoms. Seek immediate medical care if you develop signs of a severe allergic reaction (such as hives, facial swelling, or difficulty breathing) or any rapidly worsening symptom.
Tesamorelin FAQ
Is Tesamorelin the same as HGH?
Can I take this with my GLP-1?
Will I lose weight on the scale?
How fast does Tesamorelin work?
What are the side effects?
Is this FDA-approved?
What happens after I order?
How should I store and administer?
Do I need baseline labs?
How long should I stay on protocol?
What happens next
Choose Your Protocol
No consultation fee. No hidden costs. Single vials or a full 12-week cycle.
Complete Your Clinical Intake
A board-certified clinician reviews your health history, medications, and goals. Asynchronous. No appointments. No waiting rooms.
Your Prescription Ships
Compounded by a licensed U.S. pharmacy. Delivered to your door in 2-4 business days. Cold-shipped when required.
Stack Your Protocol
NAD+
NAD+ fuels the repair and energy systems inside every cell. When levels are optimized, your cells recover faster, produce energy more efficiently, and age more slowly at a molecular level. Tesamorelin builds on that foundation with a specific, clinically proven job: reducing the deep organ fat that drives metabolic dysfunction. One restores the engine. The other removes the drag.
GHK-CU
GHK-Cu is a repair signal. It tells your body to rebuild, remodel, and restore tissue from the inside out. Tesamorelin adds a targeted layer on top of that: clinically proven visceral fat reduction. One rebuilds the infrastructure. The other clears out what's weighing it down.
MOTS-C
MOTS-c works at the cellular level, flipping on your body's energy efficiency switch (a pathway called AMPK) so your cells burn fuel more effectively. Tesamorelin works at the hormonal level, telling your body to mobilize and reduce the deep fat packed around your organs. One optimizes how your cells use energy. The other redirects where your body stores it.
You've spent years working on the fat that would cooperate. This is for the fat that wouldn't.
Tesamorelin is a prescription peptide that targets visceral fat through your body's natural growth hormone system. FDA-approved. Clinician-prescribed. Delivered to your door in 2 to 4 business days.
Tesamorelin is a prescription medication. Off-label prescribing is standard medical practice. Your order initiates a clinical intake. A board-certified clinician reviews your health history before your prescription ships. If you are pregnant, breastfeeding, or have active malignancy, tesamorelin is contraindicated.
