IVUSE+ does not manufacture compounded medications. Actual product appearance and labeling of the medication you receive will differ from website images.
SEMAX.
Semax. A 7-amino acid synthetic analog of ACTH(4-10) that upregulates BDNF in the hippocampus within hours of administration. Not a stimulant. A neurotrophic signal.
*Clinician-prescribed. Ships from a licensed U.S. pharmacy.
The mechanism
Your Brain Isn't Slow. It's Undersupplied.
Cognitive decline is a supply problem. The brain depends on neurotrophic factors to maintain synaptic connections and form new ones. BDNF is the most critical. When levels drop, connections weaken, flexibility erodes, and the brain becomes less resilient to stress and aging. Semax intervenes at this supply level, restoring the signal the pituitary produces specifically for neural maintenance.
After administration, Semax crosses the blood-brain barrier and triggers a cascade: BDNF gene transcription increases 3-fold, TrkB receptors double, serotonin metabolites climb to 180% of baseline. Stimulants force the system to output more than it can sustain. Semax gives the system what it needs to operate at capacity.
Complete your intake
No appointments. No waiting rooms.
Your prescription ships
Compounded by a licensed U.S. pharmacy. Cold-shipped.
Run the course
Follow your provider's dosing schedule.
Safety
What to expect+
Semax has been used clinically in Russia for nearly three decades with an exceptional safety profile. The most common effects are mild injection site irritation, occasional headache, and rare transient restlessness. Non-habit-forming with no dependence, tolerance, or withdrawal.
Frequently asked
What is SEMAX?+
Semax is a synthetic heptapeptide derived from the 4-10 fragment of ACTH, developed in the 1980s in Russia. A small stabilizing tripeptide extends how long it stays active while keeping it small enough to cross the blood-brain barrier. Despite its ACTH origin, it has no hormonal activity, so it doesn't stimulate cortisol.
How does SEMAX work?+
It works through several parallel pathways, most notably raising BDNF and its TrkB receptor in the brain, along with serotonergic and dopaminergic modulation. BDNF is a key regulator of neuroplasticity, supporting the connections behind learning and memory. In studies, Semax increased BDNF gene transcription and made the brain more responsive to it, so it's not acting like a blunt stimulant.
What can I expect from SEMAX?+
Many people use Semax to support focus and cognitive performance, with reports of sustained executive function and a clean onset and offset. It may help your brain operate at capacity by supporting neurotrophic signaling rather than acting as a stimulant, so you're supporting the system rather than pushing it. Everyone responds differently, so results vary.
Are there any side effects?+
Semax has an excellent safety profile from nearly three decades of clinical use in Russia. The most common effects are mild injection site irritation, occasional headache, and rare transient restlessness. It's non-habit-forming, with no dependence, tolerance, or withdrawal reported.
How is SEMAX made and shipped?+
It starts with a short online medical intake, and if it's a fit, a licensed U.S. provider writes the prescription. From there it's compounded at a licensed 503A pharmacy and batch tested by a third party for sterility and potency. Then it's shipped cold-packed right to your door.
What's the best way to buy SEMAX?+
You've got two options. You can buy a one-time single vial, or you can go with the Build Your Stack subscription, which lets you mix and match the compounds in your monthly stack, starting at $189 per month. For ongoing use the stack is the better value, and you can pause, skip, or cancel anytime.
A short course of work. Your cells carry it from there.
$205.00 · Clinician-prescribed · Ships from a licensed U.S. pharmacyThese statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online consultation with a licensed provider who will determine if a prescription is appropriate.