NAD+ Nasal Spray
Steadier energy, no needle.
For human use, by prescription
Not a research chemical.
- Rx only
- Intranasal
- 300 mg/ml
- 503A compounded
NAD+ Nasal Spray.
A coenzyme present in every cell. NAD+ levels decline roughly 50% by age 50. This nasal spray delivers 300 mg/mL directly through the nasal mucosa, bypassing GI degradation.
- Provider review included
- 2-month minimum, then cancel anytime
What is NAD+ and why does it matter?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell. It plays a central role in ATP energy production, DNA repair via PARP enzymes, and sirtuin-mediated cellular signaling. NAD+ levels decline approximately 50% by age 50, a change linked to reduced mitochondrial function.
How does the nasal spray differ from IV infusions?
The nasal spray delivers NAD+ through the nasal mucosa for absorption into systemic circulation. IV infusions require clinical visits and multi-hour sessions. The nasal spray is self-administered at home without needles.
Are there any side effects?
Possible adverse reactions include constipation, headache, and shortness of breath. Some patients may experience changes in certain liver enzyme levels. Consult your prescribing provider if you experience any adverse effects.
The IVUSE+ Guarantee
Not approved, you will be refunded. Compound not working? Chat with a licensed provider for free, and swap compounds from your portal before your next charge. After your 2-month minimum, cancel from your portal. No calls, no hoops.
IVUSE+ does not manufacture compounded medications. Actual product appearance and labeling of the medication you receive will differ from website images.
What it's for
Studied for.
- Supports mitochondrial function and cellular energy production
- Promotes DNA repair through PARP enzyme activation
- Activates sirtuin enzymes that regulate cellular stress response
- Needle-free intranasal delivery for rapid absorption
Supports mitochondrial health and ATP energy production
Activates sirtuins that regulate cellular metabolism and stress responses
Powers PARP enzymes responsible for DNA repair and genomic stability
Facilitates calcium signaling through secondary messengers
Supports healthy aging and neuroprotection
Provides needle-free delivery with rapid nasal absorption
Based on preclinical and early human research. Results vary. These statements have not been evaluated by the FDA.
LongevityBuilt for the long run.
- 01Complete your intakeNo appointments. No waiting rooms.
- 02Your prescription shipsCompounded by a licensed U.S. pharmacy. Cold-shipped.
- 03Run the courseFollow your provider's dosing schedule.
Complete your intake
No appointments. No waiting rooms.
Your prescription ships
Compounded by a licensed U.S. pharmacy. Cold-shipped.
Run the course
Follow your provider's dosing schedule.
The mechanism
NAD+ Works Through Four Cellular Pathways
Nicotinamide Adenine Dinucleotide is a coenzyme already present in every cell. Your body uses it for energy production, DNA repair, and intercellular communication. NAD+ levels decline with age, dropping by roughly half after 50. This nasal spray delivers it directly through the nasal mucosa for rapid systemic absorption.
The formulation.
| Compound | Nicotinamide Adenine Dinucleotide (NAD+) |
| Concentration | 300 mg/mL |
| Format | 15 mL Nasal Spray Bottle |
| Route | Intranasal |
| Storage | Refrigerate 36–46°F |
| Pharmacy | Licensed U.S. compounding pharmacy |
Safety
What to expect+
Possible adverse reactions may include constipation, headache, and shortness of breath. Some patients may experience changes in liver enzyme levels including gamma glutamyl transferase, lactate dehydrogenase, and aspartate aminotransferase, as well as increased plasma bilirubin.
Do not use if allergic to NAD+. Not assessed for use during pregnancy. Safety has not been established for nursing mothers or children.
No known contraindications have been documented. Consult your prescribing provider before starting any new protocol.
Who should not use this+
Do not use if allergic to NAD+.
Not assessed for use during pregnancy.
Safety has not been established for nursing mothers or children.
Consult your prescribing provider before starting any new protocol.
Regulatory context+
NAD+ Nasal Spray is a compounded formulation prepared under section 503A in a licensed U.S. compounding pharmacy. It requires a prescription from a licensed healthcare provider.
Frequently asked
What is NAD+ and why does it matter?+
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell. It plays a central role in ATP energy production, DNA repair via PARP enzymes, and sirtuin-mediated cellular signaling. NAD+ levels decline approximately 50% by age 50, a change linked to reduced mitochondrial function.
How does the nasal spray differ from IV infusions?+
The nasal spray delivers NAD+ through the nasal mucosa for absorption into systemic circulation. IV infusions require clinical visits and multi-hour sessions. The nasal spray is self-administered at home without needles.
What concentration is the NAD+ Nasal Spray?+
Each bottle contains NAD+ at 300 mg/mL in a 15 mL bottle.
How should I store the nasal spray?+
Store in a refrigerator between 36 to 46 degrees F (2 to 8 degrees C). Do not freeze. Protect from light.
Are there any side effects?+
Possible adverse reactions include constipation, headache, and shortness of breath. Some patients may experience changes in certain liver enzyme levels. Consult your prescribing provider if you experience any adverse effects.
Who should not use this product?+
Do not use if you are allergic to NAD+. This product has not been assessed for use during pregnancy, and safety has not been established for nursing mothers or children. Consult your prescribing provider before starting any new protocol.
Do I need a prescription?+
Yes. NAD+ Nasal Spray is a compounded medication that requires a prescription from a licensed healthcare provider.
Can I use this alongside other peptides or supplements?+
Many protocols combine NAD+ with other compounds. Consult your prescribing provider about potential interactions and stacking recommendations specific to your health profile.
How quickly will I notice effects?+
Individual responses vary based on baseline NAD+ levels, age, and overall health. Consistency with your prescribed protocol is the primary variable.
Is this the same as taking oral NAD+ supplements?+
No. Oral NAD+ supplements face significant degradation in the gastrointestinal tract before reaching systemic circulation. Intranasal delivery bypasses the GI tract, providing a more direct route to the bloodstream.
Stack your protocol.
IVUSE+Your body. Your call.
The coenzyme behind 500+ reactions in every cell. No needles. No infusion chair.
Build Your Stack $189/mo Provider-reviewed · Ships cold from a licensed U.S. 503A pharmacyThese statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online consultation with a licensed provider who will determine if a prescription is appropriate.